In 2006, there were traces of improper access to secret Presidential files found in the White House’s network. American federal agent Leon S. Kennedy is among the group invited to the White House to investigate this incident, but when the lights suddenly go out, Leon and the SWAT team are forced to take down a horde of mysterious zombies.

Meanwhile, TerraSave staff member Claire Redfield encounters a mysterious image drawn by a youth in a country she visited, while providing support to refugees. Haunted by this drawing, which appears to be of a victim of viral infection, Claire starts her own investigation. The next morning, Claire visits the White House to request the construction of a welfare facility.

There, she has a chance reunion with Leon and uses the opportunity to show him the boy’s drawing. Leon seems to realize some sort of connection between the zombie outbreak at the White House and the strange drawing, but he tells Claire that there is no relation and leaves. In time, these two zombie outbreaks in distant countries lead to events that shake the nation to its very core.